Issue 4, 2024

Genetically encodable biosensors for Ras activity

Abstract

Genetically encoded Ras biosensors have been instrumental in illuminating the spatiotemporal dynamics of Ras activity since the beginning of the imaging revolution of the early 21st century. In general, these sensors employ Ras sensing units coupled with fluorescent proteins. These biosensors have not only helped elucidate Ras signalling dynamics at the plasma membrane but also revealed novel roles for Ras signalling within subcellular compartments such as the Golgi apparatus. In this review, we discuss the different classes of biosensors used to measure Ras activity and discuss their importance in uncovering new roles for Ras activity in cellular signalling and behavior.

Graphical abstract: Genetically encodable biosensors for Ras activity

Article information

Article type
Review Article
Submitted
26 set 2023
Accepted
02 fev 2024
First published
07 fev 2024
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2024,5, 312-320

Genetically encodable biosensors for Ras activity

R. Weeks, S. Mehta and J. Zhang, RSC Chem. Biol., 2024, 5, 312 DOI: 10.1039/D3CB00185G

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