Issue 13, 2023

Photo-/piezo-activated ultrathin molybdenum disulfide nanomedicine for synergistic tumor therapy

Abstract

Molybdenum disulfide (MoS2), as a transition metal dichalcogenide, has attracted tremendous attention owing to its remarkable electronic, physical, and chemical properties. In this study, based on the energy-converting nanomedicine, we report multifunctional two-dimensional (2D) MoS2 nanosheets with inherent plasmonic property and piezocatalytic activity for imaging-guided synergistic tumor therapy. MoS2 nanosheets display strong plasmon resonances in the near-infrared (NIR) region, especially in the second NIR biological window, possessing a notable light energy to heat effect under 1064 nm laser irradiation, which not only serves as a robust photothermal agent for cancer cell ablation but also acts as a contrast-enhanced agent for thermal imaging and photoacoustic imaging. Meanwhile, MoS2 nanosheets feature a remarkable piezotronic effect, exhibiting mechanical vibration energy to electricity under the stimulation of ultrasound-mediated microscopic pressure for reactive oxygen species generation to further kill cancer cells. The new function for old materials may open up the in-depth exploration of MoS2-based functional biomaterials in the future clinical application of imaging-guided photothermal and piezocatalytic synergetic treatment.

Graphical abstract: Photo-/piezo-activated ultrathin molybdenum disulfide nanomedicine for synergistic tumor therapy

Supplementary files

Article information

Article type
Paper
Submitted
02 fev 2023
Accepted
01 mar 2023
First published
02 mar 2023

J. Mater. Chem. B, 2023,11, 2895-2903

Photo-/piezo-activated ultrathin molybdenum disulfide nanomedicine for synergistic tumor therapy

L. Xia, J. Chen, Y. Xie, S. Zhang, W. Xia, W. Feng and Y. Chen, J. Mater. Chem. B, 2023, 11, 2895 DOI: 10.1039/D3TB00209H

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