Issue 26, 2023

An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells

Abstract

Tumor-specific drug-delivering nanocarriers could be a promising modality for next-generation tumor therapy. Here we developed a Burkitt lymphoma-specific DNA aptamer-labeled nanocarrier using the β-Annulus peptide, which forms a spherical nanoassembly called artificial viral capsid. Dynamic light scattering and transmission electron microscopy of the DNA aptamer-decorated artificial viral capsid showed the formation of spherical assemblies with a diameter of approximately 50–150 nm. The artificial viral capsid was selectively internalized into the Burkitt lymphoma cell line, Daudi, and doxorubicin complexed with the capsid selectively killed Daudi cells.

Graphical abstract: An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells

Supplementary files

Article information

Article type
Paper
Submitted
29 jan 2023
Accepted
22 mai 2023
First published
09 jun 2023
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2023,11, 6053-6059

An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells

K. Sakamoto, K. Uchiyama, T. Iwasaki, H. Inaba and K. Matsuura, J. Mater. Chem. B, 2023, 11, 6053 DOI: 10.1039/D3TB00169E

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