Issue 18, 2023

PVP-coated ultrasmall Nd-doped Gd2O2S nanoparticles for multimodal imaging

Abstract

Rare-earth (RE) based inorganic nanoparticles (NPs) are emerging nanoprobes, which have been widely explored. Single RENPs as a contrast agent for multimodal bioimaging possess the ability to combine optical, ultrasonic, magnetic and electronic properties without signal interference. In this study, we present a versatile strategy for the synthesis of 15 kinds of ultrasmall rare-earth oxysulfide (RE2O2S) NPs with a size of 3–10 nm. PVP-coated Gd0.8Nd1.2O2S NPs with a size of 6 nm are synthesized through a ligand exchange method and their colloidal stability in culture medium is studied. We demonstrate that the as-prepared NPs are capable of being employed in both T1- and T2-weighted magnetic resonance, X-ray computed tomography, photoacoustic, ultrasound, and second near infrared fluorescence imaging. The results pave the way for bioapplications of ultrasmall RE2O2S NPs.

Graphical abstract: PVP-coated ultrasmall Nd-doped Gd2O2S nanoparticles for multimodal imaging

Article information

Article type
Research Article
Submitted
12 mai 2023
Accepted
20 jun 2023
First published
03 jul 2023
This article is Open Access
Creative Commons BY-NC license

Mater. Chem. Front., 2023,7, 4109-4119

PVP-coated ultrasmall Nd-doped Gd2O2S nanoparticles for multimodal imaging

Q. Zou, L. Passini, L. Gibot, D. Lagarde, J. Hu, H. Zhu, F. Desmoulin, P. Sicard, N. Paiyabhroma, M. Verelst, R. Mauricot and C. Roux, Mater. Chem. Front., 2023, 7, 4109 DOI: 10.1039/D3QM00554B

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