Metal–organic framework-based SERS sensing platforms for life and health detection

Abstract

Advancements in life and health detection technology can greatly improve early disease diagnosis and treatment options for patients. Surface-enhanced Raman scattering (SERS) technology has become a preferred method for life and health detection due to its numerous advantages over traditional detection methods. However, the construction of SERS substrates with high sensitivity, selectivity, and repeatability remains a challenge. To overcome these challenges, metal–organic frameworks (MOFs) have emerged as promising solutions because of their unique structures and functions. The design and construction of MOF-based SERS sensing platforms with specific structures and functions are crucial to achieving the goal of life and health detection. This review outlines the synthesis strategies for MOF-based SERS substrates with various structures and functions and highlights the unique roles and performances of MOFs in SERS sensing platforms. During the detection process, MOFs can enrich trace target molecules to enhance detection sensitivity, capture selectively target molecules to improve specificity, exhibit synergistic effects to increase detection signal intensity and improve detection reproducibility and stability. Furthermore, this review explores the applications of MOF-based SERS sensing platforms in life and health detection, including breath analysis, fluid detection, and bioimaging. Finally, the challenges and opportunities faced by MOF-based SERS sensing platforms are discussed in the field of life and health detection, as well as their trend toward miniaturization and intelligentization. With continuous research and development, MOF-based SERS sensing platforms are poised to become a cornerstone of life and health monitoring in the future.