Issue 96, 2023

Decarboxylative halogenation of indoles by vanadium haloperoxidases

Abstract

Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases are capable of producing 3-haloindoles through decarboxylative halogenation of 3-carboxyindoles. This biocatalytic method is applicable to decarboxylative chlorination, bromination, and iodination in moderate to high yields and with excellent chemoselectivity.

Graphical abstract: Decarboxylative halogenation of indoles by vanadium haloperoxidases

Supplementary files

Article information

Article type
Communication
Submitted
21 ago 2023
Accepted
25 out 2023
First published
15 nov 2023

Chem. Commun., 2023,59, 14289-14292

Decarboxylative halogenation of indoles by vanadium haloperoxidases

L. J. Harstad, C. E. Wells, H. J. Lee, L. P. T. Ramos, M. Sharma, C. A. Pascoe and K. F. Biegasiewicz, Chem. Commun., 2023, 59, 14289 DOI: 10.1039/D3CC04053D

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