Issue 29, 2023

Bioinspired complexes confined in well-defined capsules: getting closer to metalloenzyme functionalities

Abstract

Reproducing the key features offered by metalloprotein binding cavities is an attractive approach to overcome the main bottlenecks of current open artificial models (in terms of stability, efficiency and selectivity). In this context, this featured article brings together selected examples of recent developments in the field of confined bioinspired complexes with an emphasis on the emerging hemicryptophane caged ligands. In particular, we focused on (1) the strategies allowing the insulation and protection of complexes sharing similarities with metalloprotein active sites, (2) the confinement-induced improvement of catalytic efficiencies and selectivities and (3) very recent efforts that have been made toward the development of bioinspired complexes equipped with weakly binding artificial cavities.

Graphical abstract: Bioinspired complexes confined in well-defined capsules: getting closer to metalloenzyme functionalities

Article information

Article type
Feature Article
Submitted
23 dez 2022
Accepted
14 mar 2023
First published
14 mar 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 4288-4299

Bioinspired complexes confined in well-defined capsules: getting closer to metalloenzyme functionalities

D. Diao, A. J. Simaan, A. Martinez and C. Colomban, Chem. Commun., 2023, 59, 4288 DOI: 10.1039/D2CC06990C

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