Issue 23, 2023

Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

Abstract

The solventless synthesis of an amide was performed in a twin-screw extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.

Graphical abstract: Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

Supplementary files

Article information

Article type
Communication
Submitted
20 dez 2022
Accepted
21 fev 2023
First published
22 fev 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 3439-3442

Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

M. Lavayssiere and F. Lamaty, Chem. Commun., 2023, 59, 3439 DOI: 10.1039/D2CC06934B

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