Issue 10, 2023

Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection

Abstract

The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) causes infections that are difficult to treat, which is due to the bacterial natural resistance to antibiotics. The bacterium is also able to form a biofilm that protects the bacterium from clearance by the human immune system and leads to chronic infection. Herein, we synthesized and characterized a novel gallium compound that interferes with both the iron metabolism and quorum sensing system of P. aeruginosa to achieve a significant bactericidal activity. The compound could substantially reduce the secretion of bacterial virulence factors as well as eliminate biofilm formation. Integrative omics analysis indicates that this compound can significantly disturb the gene transcription and metabolism of P. aeruginosa. The effectiveness of the gallium compound was further validated in mammalian cell and murine skin infection models. Our study offers a new strategy to design new gallium-based antimicrobials to combat P. aeruginosa infection.

Graphical abstract: Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection

Supplementary files

Article information

Article type
Paper
Submitted
16 mar 2023
Accepted
10 ago 2023
First published
11 ago 2023
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2023,4, 774-784

Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection

X. He, B. Han, R. Wang, Y. Guo, R. Y. T. Kao, H. Li, H. Sun and W. Xia, RSC Chem. Biol., 2023, 4, 774 DOI: 10.1039/D3CB00033H

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