Issue 22, 2022

An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C[double bond, length as m-dash]O and C[double bond, length as m-dash]N bonds

Abstract

Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first examples were reported 18 years ago by Akiyama and Terada. Although they were originally developed for enantioselective additions to imines, a wide reaction scope has been demonstrated using this type of catalyst. In this review, the known applications of CPA for enantioselective additions to C[double bond, length as m-dash]O and C[double bond, length as m-dash]N bonds are covered.

Graphical abstract: An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C [[double bond, length as m-dash]] O and C [[double bond, length as m-dash]] N bonds

Associated articles

Article information

Article type
Review Article
Submitted
28 jul 2022
Accepted
06 set 2022
First published
07 set 2022

Org. Chem. Front., 2022,9, 6331-6399

An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C[double bond, length as m-dash]O and C[double bond, length as m-dash]N bonds

X. del Corte, E. Martínez de Marigorta, F. Palacios, J. Vicario and A. Maestro, Org. Chem. Front., 2022, 9, 6331 DOI: 10.1039/D2QO01209J

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