Issue 18, 2022

Merging dearomatization with redox-neutral C(sp3)–H functionalization via hydride transfer/cyclization: recent advances and perspectives

Abstract

Dearomatization and direct C(sp3)–H functionalization represent two hot research fields in organic synthesis, the merging of which is among the most challenging but appealing topics. The emerging hydride transfer-involved dearomatization reaction can achieve this goal in an efficient redox-neutral manner, and encouraging progress has been made in this area during the past decade. Herein, we would like to give a timely account of the topic, and this review is categorized according to the hydride acceptors, namely vinylogous imines and quinone methides, which initiate the cascade hydride transfer/dearomative cyclization process to dearomatize indoles and phenols, respectively. Moreover, the limitations, challenges and future directions are also pointed out.

Graphical abstract: Merging dearomatization with redox-neutral C(sp3)–H functionalization via hydride transfer/cyclization: recent advances and perspectives

Article information

Article type
Review Article
Submitted
02 jul 2022
Accepted
27 jul 2022
First published
04 ago 2022

Org. Chem. Front., 2022,9, 5041-5052

Merging dearomatization with redox-neutral C(sp3)–H functionalization via hydride transfer/cyclization: recent advances and perspectives

F. Hu, Y. Shen, L. Wang and S. Li, Org. Chem. Front., 2022, 9, 5041 DOI: 10.1039/D2QO01054B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements