Issue 22, 2022

Supercritical carbon dioxide as reaction medium for selective hydrogenation of fluorinated arenes

Abstract

The selective hydrogenation of fluorinated arenes with polar functionalities is achieved, opening a versatile pathway for the production of valuable substituted fluorocyclohexane derivatives from readily available substrates. The use of supercritical carbon dioxide (scCO2) as a hydrophobic and green solvent in combination with Rh nanoparticles immobilized on molecularly modified silica as catalysts favours hydrogenation over hydrodefluorination. The approach compares favourably in terms of green chemistry metrics relative to traditional synthetic routes as exemplified for the useful building block 4-fluorocyclohexan-1-ol.

Graphical abstract: Supercritical carbon dioxide as reaction medium for selective hydrogenation of fluorinated arenes

Supplementary files

Article information

Article type
Communication
Submitted
15 jul 2022
Accepted
27 ago 2022
First published
07 set 2022
This article is Open Access
Creative Commons BY license

Green Chem., 2022,24, 8671-8676

Supercritical carbon dioxide as reaction medium for selective hydrogenation of fluorinated arenes

S. Kacem, Y. Qiao, C. Wirtz, N. Theyssen, A. Bordet and W. Leitner, Green Chem., 2022, 24, 8671 DOI: 10.1039/D2GC02623F

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