Issue 43, 2021

Defective Ag–In–S/ZnS quantum dots: an oxygen-derived free radical scavenger for mitigating macrophage inflammation

Abstract

Oxidative stress plays an important role in the development of inflammatory diseases including allergy, heart disease, diabetes and cancer. Nanomaterial-mediated antioxidant therapy is regarded as a promising strategy to treat oxidative stress-mediated inflammation. Herein, defective Ag–In–S/ZnS quantum dots (AIS/ZnS QDs) with oxygen-derived radical-scavenging capabilities are developed. Owing to their intrinsic defects and abundant surface functional groups, these quantum dots exhibit excellent oxygen-derived free radical removal efficiency in vitro. In macrophages, AIS/ZnS QDs can eliminate intracellular excessive ROS stimulated by either H2O2 or lipopolysaccharide (LPS), thus can effectively protect macrophages against ROS-induced oxidative injury. Moreover, in the model of LPS-triggered macrophage inflammation, they exhibit benign anti-inflammatory ability by inhibiting the expression of related proinflammatory cytokines (e.g., TNF-α and IL-6). These findings indicate that AIS/ZnS QDs hold great potential for the treatment of ROS-related inflammatory disorders.

Graphical abstract: Defective Ag–In–S/ZnS quantum dots: an oxygen-derived free radical scavenger for mitigating macrophage inflammation

Supplementary files

Article information

Article type
Paper
Submitted
02 ago 2021
Accepted
23 set 2021
First published
27 set 2021

J. Mater. Chem. B, 2021,9, 8971-8979

Defective Ag–In–S/ZnS quantum dots: an oxygen-derived free radical scavenger for mitigating macrophage inflammation

N. Gao, J. Jing, H. Zhao, Y. Liu, C. Yang, M. Gao, B. Chen, R. Zhang and X. Zhang, J. Mater. Chem. B, 2021, 9, 8971 DOI: 10.1039/D1TB01681D

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