Issue 60, 2021

Influence of water-soluble pillararene hosts on Kemp elimination

Abstract

Since pillar[5]arene was first discovered in 2008, it has developed into a multifunctional supramolecular host. Its application covers many fields from drug delivery and chemical sensing to the construction of molecular machines, and so on. Supramolecular catalysis based on pillar[n]arenes is one of the hot research topics that has emerged in recent years. In this paper, we have synthesized two water-soluble pillar[5]arenes with peripheral rims bearing opposite charges and investigated their influence on Kemp elimination reaction of 1,2-phenylisoxazole derivatives. It is found that both hosts have a moderate rate acceleration effect on the reaction, and the positively charged host H1 has a greater impact on the reaction rate than the negatively charged host H2.

Graphical abstract: Influence of water-soluble pillararene hosts on Kemp elimination

Article information

Article type
Paper
Submitted
29 out 2021
Accepted
22 nov 2021
First published
26 nov 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 38115-38119

Influence of water-soluble pillararene hosts on Kemp elimination

Q. Liu, X. Tian, Y. Shen, X. Huang, K. Wang and X. Hu, RSC Adv., 2021, 11, 38115 DOI: 10.1039/D1RA07958A

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