Issue 14, 2021

Rhodium(iii) catalyzed olefination and deuteration of tetrahydrocarbazole

Abstract

The rhodium-catalyzed olefination and deuteration of tetrahydrocarbazoles in water with the aid of an N,N-dimethylcarbamoyl-protected group is presented. This olefination method features a broad substrate scope, good functional-group tolerance, and high efficiency in water. Practical applications of the protocol are illustrated by the synthesis of various evodiamine derivatives. As such, this environmentally friendly approach to directly modify natural products will attract much attention in academic and industrial research.

Graphical abstract: Rhodium(iii) catalyzed olefination and deuteration of tetrahydrocarbazole

Supplementary files

Article information

Article type
Paper
Submitted
11 jan 2021
Accepted
25 jan 2021
First published
23 fev 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 8356-8361

Rhodium(III) catalyzed olefination and deuteration of tetrahydrocarbazole

W. Peng, Q. Liu, F. Yin, C. Shi, L. Ji, L. Qu, C. Wang, H. Luo, L. Kong and X. Wang, RSC Adv., 2021, 11, 8356 DOI: 10.1039/D1RA00236H

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