Issue 5, 2021

Stereoselective synthesis and applications of spirocyclic oxindoles

Abstract

The development of novel synthetic strategies to form new chemical entities in a stereoselective manner is an ongoing significant objective in organic and medicinal chemistry. This review analyses the development of new stereoselective approaches to spirocyclic oxindoles with spiro-3- to 8-membered rings. It highlights the importance of these structures for applications in medicinal chemistry, as intermediates or final products in total synthesis and as model compounds for the development of enantioselective catalytic methodologies.

Graphical abstract: Stereoselective synthesis and applications of spirocyclic oxindoles

Article information

Article type
Review Article
Submitted
11 set 2020
Accepted
05 jan 2021
First published
06 jan 2021
This article is Open Access
Creative Commons BY license

Org. Chem. Front., 2021,8, 1026-1084

Stereoselective synthesis and applications of spirocyclic oxindoles

A. J. Boddy and J. A. Bull, Org. Chem. Front., 2021, 8, 1026 DOI: 10.1039/D0QO01085E

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