Issue 38, 2021

Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules

Abstract

Alkynes were employed as tags to observe small molecules in cells by Raman microscopy. Herein, simple deuteration was found to shift the vibrational frequency of the alkyne by 135 cm−1. Two-color Raman imaging of D-alkynes and H-alkynes made it possible to distinguish between and observe similar small molecules in live cells.

Graphical abstract: Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules

Supplementary files

Article information

Article type
Communication
Submitted
28 jul 2021
Accepted
26 ago 2021
First published
16 set 2021
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2021,19, 8232-8236

Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules

S. Egoshi, K. Dodo, K. Ohgane and M. Sodeoka, Org. Biomol. Chem., 2021, 19, 8232 DOI: 10.1039/D1OB01479J

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