Issue 25, 2021

Recent advances in [3+2] cycloaddition of allenes with 1,3-carbonyl ylides; Rh(ii)-catalyzed access to bridged polyoxocarbocyles

Abstract

This study summarizes the stereochemical outcomes of [3+2] cycloaddition of allene molecules with 1,3-dipolar carbonyl ylides derived from rhodium carbene-mediated diazo decomposition for the formation of highly diastereoselective poly oxacarbocycles. Since only rhodium is employed for this purpose, further exploration of the reaction with other transition metals is lacking. A little research in this area surely depicts the need for further exploration of this technique using other transition metals and ylides (sulfur and nitrogen) for the synthesis of oxa-, aza-, and thia-bridged heterocarbocycles. These polyheterocycles will be future drug candidates being structurally analogous to anthecularin, artemisinin, englerin and intracarene. This review presents a future outlook for organic chemists for further exploration of the synthesis of bridged polyheterocarbocycles.

Graphical abstract: Recent advances in [3+2] cycloaddition of allenes with 1,3-carbonyl ylides; Rh(ii)-catalyzed access to bridged polyoxocarbocyles

Article information

Article type
Perspective
Submitted
26 abr 2021
Accepted
31 mai 2021
First published
01 jun 2021

New J. Chem., 2021,45, 11018-11029

Recent advances in [3+2] cycloaddition of allenes with 1,3-carbonyl ylides; Rh(II)-catalyzed access to bridged polyoxocarbocyles

S. K. Sahu, P. K. Behera, P. Choudhury, M. Sethi, S. Jena and L. Rout, New J. Chem., 2021, 45, 11018 DOI: 10.1039/D1NJ02034J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements