Issue 97, 2021

Recent advances in the synthesis of N-heteroarenes via catalytic dehydrogenation of N-heterocycles

Abstract

Bio-active molecules having N-heteroarene core are widely used for numerous medicinal applications and as lifesaving drugs. In this direction, dehydrogenation of partially saturated aromatic N-heterocycles shows utmost importance for the synthesis of heterocycles. This feature article highlights the recent advances, from 2009 to April 2021, on the dehydrogenation of N-heteroaromatics. Notable features considering the development of newer catalysis for dehydrogenations are: (i) approaches based on precious metal catalysis, (ii) newer strategies and catalyst development technology using non-precious metal-catalysts for N-heterocycles having one or more heteroatoms, (iii) Synthesis of five or six-membered N-heterocycles using photocatalysis, electrocatalytic, and organo-catalytic approaches using different homogeneous and heterogeneous conditions’ (iv) metal free (base and acid-promoted) dehydrogenation along with I2, N-hydroxyphthalimide (NHPI) and bio catalyzed miscellaneous examples have also been discussed, (v) mechanistic studies for various dehydrogenation reactions and (vi) synthetic applications of various bio-active molecules including post-drug derivatization are discussed.

Graphical abstract: Recent advances in the synthesis of N-heteroarenes via catalytic dehydrogenation of N-heterocycles

Article information

Article type
Feature Article
Submitted
01 set 2021
Accepted
27 out 2021
First published
27 out 2021

Chem. Commun., 2021,57, 13042-13058

Recent advances in the synthesis of N-heteroarenes via catalytic dehydrogenation of N-heterocycles

A. Bera, S. Bera and D. Banerjee, Chem. Commun., 2021, 57, 13042 DOI: 10.1039/D1CC04919D

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