Issue 77, 2021

Recent advances in transition metal-catalyzed (1,n) annulation using (de)-hydrogenative coupling with alcohols

Abstract

(1,n) annulation reactions using (de)-hydrogenative coupling with alcohols or diols represent a straightforward technique for the synthesis of cyclic moieties. Utilization of such renewable resources for chemical transformations in a one-pot manner is the main focus, which avoids generation of stoichiometric waste. Application of such (1,n) annulation approaches drives the catalysis research in a more sustainable way and generates dihydrogen and water as by-products. This feature article highlights the recent (from 2015 to March 2021) progress in the synthesis of stereo-selective cycloalkanes and cycloalkenes, saturated and unsaturated N-heterocycles (cyclic amine, imide, lactam, tetrahydro β-carboline, quinazoline, quinazolinone, 1,3,5-triazines etc.) and other N-heterocycles with the formation of multiple bonds in a one pot operation. Mechanistic studies, new catalytic approaches, and synthetic applications including drug synthesis and post-drug derivatization, scope, and limitations are discussed.

Graphical abstract: Recent advances in transition metal-catalyzed (1,n) annulation using (de)-hydrogenative coupling with alcohols

Article information

Article type
Feature Article
Submitted
25 jun 2021
Accepted
06 ago 2021
First published
06 ago 2021

Chem. Commun., 2021,57, 9807-9819

Recent advances in transition metal-catalyzed (1,n) annulation using (de)-hydrogenative coupling with alcohols

S. Bera, L. M. Kabadwal and D. Banerjee, Chem. Commun., 2021, 57, 9807 DOI: 10.1039/D1CC03404A

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