Issue 42, 2020

A minireview of viscosity-sensitive fluorescent probes: design and biological applications

Abstract

Microenvironment-related parameters like viscosity, polarity, and pH play important roles in controlling the physical or chemical behaviors of local molecules, which determine the physical or chemical behaviors of surrounding molecules. In general, changes of the internal microenvironment will usually lead to cellular malfunction or the occurrence of relevant diseases. In the last few decades, the field of chemicobiology has received great attention. Also, remarkable progress has been made in developing viscosity-sensitive fluorescent probes. These probes were particularly efficient for imaging viscosity in biomembranes as well as lighting up specific organelles, such as mitochondria and lysosome. Besides, there are some fluorescent probes that can be used to quantify intracellular viscosity when combined with fluorescence lifetime (FLIM) and ratiometric imaging under water-free conditions. In this review, we summarized the majority of viscosity-sensitive chemosensors that have been reported thus far.

Graphical abstract: A minireview of viscosity-sensitive fluorescent probes: design and biological applications

Article information

Article type
Review Article
Submitted
03 mai 2020
Accepted
19 jul 2020
First published
02 set 2020

J. Mater. Chem. B, 2020,8, 9642-9651

A minireview of viscosity-sensitive fluorescent probes: design and biological applications

C. Ma, W. Sun, L. Xu, Y. Qian, J. Dai, G. Zhong, Y. Hou, J. Liu and B. Shen, J. Mater. Chem. B, 2020, 8, 9642 DOI: 10.1039/D0TB01146K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements