Issue 28, 2020

Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

Abstract

Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP–polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking. It is possible to introduce isoniazid, which is the most employed antibiotic for tuberculosis treatment, into the hydrogels without disrupting the hydrogel structure at appropriate concentrations for oral administration.

Graphical abstract: Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

Supplementary files

Article information

Article type
Paper
Submitted
19 abr 2020
Accepted
09 jun 2020
First published
10 jun 2020

Soft Matter, 2020,16, 6514-6522

Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

A. Lopera, J. A. Aguilar, R. Belda, B. Verdejo, J. W. Steed and E. García-España, Soft Matter, 2020, 16, 6514 DOI: 10.1039/D0SM00704H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements