Issue 6, 2020

C-2 auxiliaries for stereoselective glycosylation based on common additive functional groups

Abstract

The stereoselective introduction of the glycosidic bond is one of the main challenges in chemical oligosaccharide synthesis. Stereoselective glycosylation can be achieved using neighbouring group participation of a C-2 auxiliary or using additives, for example. Both methods aim to generate a defined reactive intermediate that reacts in a stereoselective manner with alcohol nucleophiles. This inspired us to develop new C-2 auxiliaries based on commonly used additive functionalities such as ethers, phosphine oxides and tertiary amides. Good 1,2-trans-selectivity was observed for the phosphine oxide and amide-based auxiliaries expanding the toolbox with new auxiliaries for stereoselective glycosylation reactions.

Graphical abstract: C-2 auxiliaries for stereoselective glycosylation based on common additive functional groups

Supplementary files

Article information

Article type
Paper
Submitted
19 dez 2019
Accepted
16 jan 2020
First published
16 jan 2020
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2020,18, 1165-1184

C-2 auxiliaries for stereoselective glycosylation based on common additive functional groups

F. F. J. de Kleijne, S. J. Moons, P. B. White and T. J. Boltje, Org. Biomol. Chem., 2020, 18, 1165 DOI: 10.1039/C9OB02700A

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