Issue 4, 2020

Activatable cell-penetrating peptides: 15 years of research

Abstract

An important hurdle for the intracellular delivery of large cargo is the cellular membrane, which protects the cell from exogenous substances. Cell-penetrating peptides (CPPs) can cross this barrier but their use as drug delivery vehicles is hampered by their lack of cell type specificity. Over the past years, several approaches have been explored to control the activity of CPPs that can be primed for cellular uptake. Since the first report on such activatable CPPs (ACPPs) in 2004, various methods of activation have been developed. Here, we provide an overview of the different ACPPs strategies known to date and summarize the benefits, drawbacks, and future directions.

Graphical abstract: Activatable cell-penetrating peptides: 15 years of research

Article information

Article type
Review Article
Submitted
03 jul 2020
Accepted
13 ago 2020
First published
26 ago 2020
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2020,1, 192-203

Activatable cell-penetrating peptides: 15 years of research

H. de Jong, K. M. Bonger and D. W. P. M. Löwik, RSC Chem. Biol., 2020, 1, 192 DOI: 10.1039/D0CB00114G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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