Issue 13, 2019

Polyrotaxane-based biointerfaces with dynamic biomaterial functions

Abstract

The molecular mobility of cyclic molecules (e.g. α-cyclodextrins) threaded along a linear polymer chain (e.g. poly(ethylene glycol)) in polyrotaxanes is a unique feature for biomaterials with dynamic functionality. Surfaces with molecular mobility can be obtained by introducing polyrotaxanes. The molecular mobility of polyrotaxane-based surfaces can be modulated by changing the number of threaded cyclic molecules and modifying their functional groups. Biological ligands modified with α-cyclodextrins exhibit increased multivalent interactions with their receptors due to the molecular mobility of the latter. Furthermore, polyrotaxane-based surfaces not only improve the initial response of cells via multivalent interactions, but also affect cytoskeleton formation and the inherent quality of cells, including differentiation. Such polyrotaxane surfaces can emerge as new biointerfaces that can adapt to the dynamic biological nature.

Graphical abstract: Polyrotaxane-based biointerfaces with dynamic biomaterial functions

Article information

Article type
Review Article
Submitted
04 fev 2019
Accepted
22 fev 2019
First published
22 fev 2019

J. Mater. Chem. B, 2019,7, 2123-2129

Polyrotaxane-based biointerfaces with dynamic biomaterial functions

Y. Arisaka and N. Yui, J. Mater. Chem. B, 2019, 7, 2123 DOI: 10.1039/C9TB00256A

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