Issue 63, 2019

A novel drug–drug nanohybrid for the self-delivery of porphyrin and cis-platinum

Abstract

The thriving development of nanotechnology has greatly promoted the development of drug delivery systems (DDSs) in the past decades. However, most DDSs themselves cannot serve as diagnostic reagents and must be metabolized, by which they may become poisonous and even cause immune reactions. In this study, a novel self-delivery drug–drug system (SDDS) nanohybrid based on the coordination assembly of a photodynamic reagent, tetra-(4-carboxyphenyl)porphyrin (TCPP), and a chemotherapy reagent, cis-platinum, was designed and synthesized. The four carboxyl groups of TCPP can compete with the chloride ions of cis-platinum by coordination interactions, forming a TCPP-cis-platinum nanohybrid (PCNH) for the purpose of photodynamic/chemotherapeutic synergistic treatment with a combinational index of 0.28. Meanwhile, the PCNH system can effectively protect the photosensitizer TCPP from photobleaching when irradiated continuously in the photodynamic therapy (PDT) process, which is very crucial for PDT. Furthermore, introduction of the heavy atom platinum can greatly enhance the producing efficiency of 1O2 by 46%. In addition, the red emission fluorescence of TCPP is beneficial for monitoring and tracing the process of drug delivery when used in vitro. This work may pave a new way for the design of new integrated nanohybrids for diagnosis and synergistic treatment.

Graphical abstract: A novel drug–drug nanohybrid for the self-delivery of porphyrin and cis-platinum

Supplementary files

Article information

Article type
Paper
Submitted
04 set 2019
Accepted
23 out 2019
First published
12 nov 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 37003-37008

A novel drug–drug nanohybrid for the self-delivery of porphyrin and cis-platinum

C. Shan, J. Ru, M. Zhang, J. Cao, W. Liu, H. Guo and Y. Tang, RSC Adv., 2019, 9, 37003 DOI: 10.1039/C9RA07085K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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