Issue 13, 2019

Visible-light-induced radical trifluoromethylthiolation of N-(o-cyanobiaryl)acrylamides

Abstract

An efficient and general visible-light-mediated trifluoromethylthiolation of N-(o-cyanobiaryl)acrylamides has been successfully accomplished using N-trifluoromethylthiosaccharin as an effective source of SCF3 radicals. The reaction was proposed to proceed via a domino radical trifluoromethylthiolation/cyano insertion/cyclization to afford the corresponding SCF3-containing ring-fused phenanthridine derivatives in moderate to good yields.

Graphical abstract: Visible-light-induced radical trifluoromethylthiolation of N-(o-cyanobiaryl)acrylamides

Supplementary files

Article information

Article type
Paper
Submitted
11 fev 2019
Accepted
01 mar 2019
First published
02 mar 2019

Org. Biomol. Chem., 2019,17, 3374-3380

Visible-light-induced radical trifluoromethylthiolation of N-(o-cyanobiaryl)acrylamides

M. Zhu, W. Fu, W. Guo, Y. Tian, Z. Wang and B. Ji, Org. Biomol. Chem., 2019, 17, 3374 DOI: 10.1039/C9OB00342H

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