Issue 5, 2019

Understanding the good and poor cell targeting activity of gold nanostructures functionalized with molecular units for the epidermal growth factor receptor

Abstract

Nanostructures can strongly interact with cells or other biological structures; furthermore when they are functionalized with targeting units, they are of great interest for a variety of applications in the biotechnology field like those for efficient imaging, diagnosis and therapy and in particular for cancer theranostics. Obtaining targeting with good specificity and sensitivity is a key necessity, which, however, is affected by the complexity of the interactions between the nanostructures and the biological components. In this work we report the study of specificity and sensitivity of gold nanoparticles functionalized with the peptide GE11 for the targeting of the epidermal growth factor receptor, expressed on many cells and, in particular, on many types of cancer cells. We show how a combination of spectroscopic measurements and molecular dynamics simulations allows the comprehension of the targeting activity of peptides linked to the surface of gold nanostructures and how the targeting is tuned by the presence of polyethylene glycol chains.

Graphical abstract: Understanding the good and poor cell targeting activity of gold nanostructures functionalized with molecular units for the epidermal growth factor receptor

Supplementary files

Article information

Article type
Paper
Submitted
17 fev 2019
Accepted
29 mar 2019
First published
29 mar 2019
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2019,1, 1970-1979

Understanding the good and poor cell targeting activity of gold nanostructures functionalized with molecular units for the epidermal growth factor receptor

C. Mazzuca, B. Di Napoli, F. Biscaglia, G. Ripani, S. Rajendran, A. Braga, C. Benna, S. Mocellin, M. Gobbo, M. Meneghetti and A. Palleschi, Nanoscale Adv., 2019, 1, 1970 DOI: 10.1039/C9NA00096H

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