Issue 26, 2018

Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

Abstract

The first iridium-catalyzed enantioselective vinylogous allylic alkylation of coumarins is presented. Using easily accessible linear allylic carbonates as the allylic electrophile, this reaction installs unfunctionalized allyl groups at the γ-position of 4-methylcoumarins in an exclusively branched-selective manner generally in high yields with an excellent level of enantioselectivity (up to 99 : 1 er).

Graphical abstract: Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

Supplementary files

Article information

Article type
Edge Article
Submitted
07 mai 2018
Accepted
03 jun 2018
First published
04 jun 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2018,9, 5767-5772

Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins

R. Sarkar, S. Mitra and S. Mukherjee, Chem. Sci., 2018, 9, 5767 DOI: 10.1039/C8SC02041H

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