Issue 37, 2018

Antibacterial coordination polymer hydrogels composed of silver(i)-PEGylated bisimidazolylbenzyl alcohol

Abstract

Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water via coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (1a–c). These coordination polymer hydrogels exhibit much better antibacterial activity than silver nitrate against both Gram-negative and Gram-positive pathogens including multidrug-resistant pathogens. The coordination polymer Ag/1c with a long PEG chain (PEG1000) was demonstrated to be the most effective antibacterial material, and its minimum inhibition concentrations (MICs) could be as low as 15.2 times for common Staphylococcus aureus and 4.8 times for methicillin-resistant Staphylococcus aureus over that of silver nitrate. With improved antibacterial performance, easy preparation method, improved stability, sustained releasability, outstanding ductility and low cytotoxicity, the as-prepared coordination polymer hydrogels should find various potential applications such as in clinical burn and wound dressings, biofilms, bioadhesives, and coatings of biomedical materials.

Graphical abstract: Antibacterial coordination polymer hydrogels composed of silver(i)-PEGylated bisimidazolylbenzyl alcohol

Supplementary files

Article information

Article type
Paper
Submitted
23 jan 2018
Accepted
22 mai 2018
First published
06 jun 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 20829-20835

Antibacterial coordination polymer hydrogels composed of silver(I)-PEGylated bisimidazolylbenzyl alcohol

F. Wu, D. He, L. Chen, F. Liu, H. Huang, J. Dai, S. Zhang and J. You, RSC Adv., 2018, 8, 20829 DOI: 10.1039/C8RA00682B

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