Issue 18, 2018

Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

Abstract

Moving to ultra-low (<100 nL) sample volumes presents numerous challenges, many of which can be resolved by implementation of open nanofluidic films. These nanofluidic films are fabricated using a hexagonal network of gold-coated open microchannels which capture all of the following innovative advantages: (1) sample volumes of <100 nL cm−2; (2) zero analyte exchange and loss with the film materials; (3) rapid and omni-directional wicking transport of >500 nL min−1 per square of film; (4) ultra-simple roll-to-roll fabrication; (5) stable and bio-compatible super-hydrophilicity for weeks in air by peptide surface modification. Validation includes both detailed in vitro characterization and in vivo validation with sweat transport from the human skin. Sampling times (skin-to-sensor) of <3 min were achieved, setting new benchmarks for the field of wearable sweat sensing. This work addresses significant challenges for sweat biosensing, or for any other nano-liter regime (<100 nL) fluid sampling and sensing application.

Graphical abstract: Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

Supplementary files

Article information

Article type
Paper
Submitted
15 fev 2018
Accepted
04 jul 2018
First published
13 jul 2018

Lab Chip, 2018,18, 2816-2825

Author version available

Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

N. B. Twine, R. M. Norton, M. C. Brothers, A. Hauke, E. F. Gomez and J. Heikenfeld, Lab Chip, 2018, 18, 2816 DOI: 10.1039/C8LC00186C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements