Issue 1, 2017

A facile approach for the trifluoromethylthiolation of methylenecyclopropanes

Abstract

A facile approach for the trifluoromethylthiolation of methylenecyclopropanes (MCPs) has been developed by using AgSCF3/Na2S2O8 as a trifluoromethylthiolation source (SCF3) to give trifluoromethylthiolated 1,2-dihydro-naphthalene derivatives in moderate to good yields, and the reaction has been proven to go through a radical-type pathway. The products can easily be aromatized upon oxidation, offering a new method for the construction of trifluoromethylthiolated naphthalenes.

Graphical abstract: A facile approach for the trifluoromethylthiolation of methylenecyclopropanes

Supplementary files

Article information

Article type
Research Article
Submitted
12 set 2016
Accepted
19 out 2016
First published
20 out 2016

Org. Chem. Front., 2017,4, 86-90

A facile approach for the trifluoromethylthiolation of methylenecyclopropanes

M. Chen, X. Tang and M. Shi, Org. Chem. Front., 2017, 4, 86 DOI: 10.1039/C6QO00536E

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