Issue 29, 2016

Unusual seeding effect in the liquid-assisted high-pressure polymorphism of chlorpropamide

Abstract

When crystals of four polymorphs – a stable α-form and three metastable ones (β-, γ-, δ-forms) – are simultaneously present in a pressure cell, immersed in a 1 : 1 pentane–isopentane mixture, the least stable β-form recrystallises exclusively into the γ-form (if no δ-form seed is present) or concomitantly into the γ- and δ-forms (if a seed of the δ-form is present). However, the β-form never recrystallises to the stable α-form, even if the latter is also present as a potential seed.

Graphical abstract: Unusual seeding effect in the liquid-assisted high-pressure polymorphism of chlorpropamide

Supplementary files

Article information

Article type
Communication
Submitted
30 mar 2016
Accepted
06 jun 2016
First published
06 jun 2016
This article is Open Access
Creative Commons BY-NC license

CrystEngComm, 2016,18, 5423-5428

Unusual seeding effect in the liquid-assisted high-pressure polymorphism of chlorpropamide

B. A. Zakharov, S. V. Goryainov and E. V. Boldyreva, CrystEngComm, 2016, 18, 5423 DOI: 10.1039/C6CE00711B

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