Issue 58, 2016

Development of a disaggregation-induced emission probe for the detection of RecA inteins from Mycobacterium tuberculosis

Abstract

A fluorescent sensor – InR – with disaggregation-induced emission (DIE) characteristics has been developed for the label free detection of RecA inteins from Mycobacterium tuberculosis. Mechanistic studies demonstrate that InR binds at a hydrophobic pocket of RecA inteins, which is constituted by Gly435, Glu434, Arg405 and Arg 7, resulting in the disaggregation and recovery of its fluorescence.

Graphical abstract: Development of a disaggregation-induced emission probe for the detection of RecA inteins from Mycobacterium tuberculosis

Supplementary files

Article information

Article type
Communication
Submitted
16 jan 2016
Accepted
19 fev 2016
First published
19 fev 2016

Chem. Commun., 2016,52, 9086-9088

Development of a disaggregation-induced emission probe for the detection of RecA inteins from Mycobacterium tuberculosis

X. Li, H. Jiang, Z. Luo, Y. Chang and L. Zhang, Chem. Commun., 2016, 52, 9086 DOI: 10.1039/C6CC00439C

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