Issue 5, 2015

Enantioselective synthesis of 4,5,6,7-tetrahydroindoles via olefin cross-metathesis/intramolecular Friedel–Crafts alkylation reaction of pyrroles

Abstract

A sequential catalysis involving olefin cross-metathesis/asymmetric intramolecular Friedel–Crafts alkylation of pyrrole derivatives has been developed. A variety of enantioenriched 4,5,6,7-tetrahydroindoles were obtained in good yields and enantioselectivity by combining a Zhan-1B catalyst with a chiral phosphoric acid.

Graphical abstract: Enantioselective synthesis of 4,5,6,7-tetrahydroindoles via olefin cross-metathesis/intramolecular Friedel–Crafts alkylation reaction of pyrroles

Supplementary files

Article information

Article type
Research Article
Submitted
27 jan 2015
Accepted
21 fev 2015
First published
02 mar 2015

Org. Chem. Front., 2015,2, 476-480

Enantioselective synthesis of 4,5,6,7-tetrahydroindoles via olefin cross-metathesis/intramolecular Friedel–Crafts alkylation reaction of pyrroles

J. Zhang, X. Liu, Q. Gu, X. Shi and S. You, Org. Chem. Front., 2015, 2, 476 DOI: 10.1039/C5QO00034C

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