Issue 6, 2015

The Mitsunobu reaction in the 21st century

Abstract

The Mitsunobu reaction was first described almost fifty years ago and has enjoyed immense popularity since its inception. The purpose of this review is to focus on the more recent advances and applications of Mitsunobu chemistry, particularly from the 1990s to the present day. In addition to a discussion of newer reagents that facilitate purification, we will describe more contemporary applications of this chemistry, especially as applied to the synthesis of pharmaceuticals and their precursors.

Graphical abstract: The Mitsunobu reaction in the 21st century

Article information

Article type
Review Article
Submitted
13 jan 2015
Accepted
12 mar 2015
First published
17 mar 2015

Org. Chem. Front., 2015,2, 739-752

Author version available

The Mitsunobu reaction in the 21st century

S. Fletcher, Org. Chem. Front., 2015, 2, 739 DOI: 10.1039/C5QO00016E

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