Issue 6, 2015

Anion binding and transport properties of cyclic 2,6-bis(1,2,3-triazol-1-yl)pyridines

Abstract

A series of cyclic 2,6-bis-(1,2,3-triazolyl)-pyridine anion receptors with thiourea functionalities were synthesized by click reaction of 2,6-diazidopyridine with protected propargylamine followed by condensation of a bisthiocyanate derivative with a series of diamines. Their chloride binding affinities as well as their transport properties in POPC bilayers were examined. These receptors were found to function as anion carriers, which can mediate both Cl/NO3 antiport and H+/Cl symport, and the transport activity of these hosts were dominated by their lipophilicity.

Graphical abstract: Anion binding and transport properties of cyclic 2,6-bis(1,2,3-triazol-1-yl)pyridines

Supplementary files

Article information

Article type
Paper
Submitted
21 out 2014
Accepted
17 nov 2014
First published
01 dez 2014
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 1654-1661

Author version available

Anion binding and transport properties of cyclic 2,6-bis(1,2,3-triazol-1-yl)pyridines

T. Merckx, C. J. E. Haynes, L. E. Karagiannidis, H. J. Clarke, K. Holder, A. Kelly, G. J. Tizzard, S. J. Coles, P. Verwilst, P. A. Gale and W. Dehaen, Org. Biomol. Chem., 2015, 13, 1654 DOI: 10.1039/C4OB02236J

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