Issue 1, 2015

Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

Abstract

We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.

Graphical abstract: Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

Supplementary files

Article information

Article type
Communication
Submitted
27 set 2014
Accepted
22 out 2014
First published
06 nov 2014
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2015,13, 64-67

Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

N. Chuard, G. Gasparini, A. Roux, N. Sakai and S. Matile, Org. Biomol. Chem., 2015, 13, 64 DOI: 10.1039/C4OB02060J

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