Issue 60, 2014

A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

Abstract

We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that NpFR1 is sensitive to redox changes within living cells.

Graphical abstract: A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

Supplementary files

Article information

Article type
Communication
Submitted
08 mai 2014
Accepted
05 jun 2014
First published
05 jun 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 8181-8184

A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

J. Yeow, A. Kaur, M. D. Anscomb and E. J. New, Chem. Commun., 2014, 50, 8181 DOI: 10.1039/C4CC03464C

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