Issue 9, 2011

A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding

Abstract

Variation of water content in liquid-assisted grinding was utilised to mechanochemically screen for different hydrated forms of magnesium naproxen directly from a mixture of magnesium oxide and naproxen. Structure determination from powder and single crystal X-ray diffraction data, supported by solid-state NMR and synchrotron radiation diffraction experiments, revealed a monohydrate coordination polymer, a discrete tetrahydrate complex, and provided a preliminary structural model for a highly hydrated salt.

Graphical abstract: A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding

Supplementary files

Article information

Article type
Communication
Submitted
26 nov 2010
Accepted
24 jan 2011
First published
15 fev 2011

CrystEngComm, 2011,13, 3125-3129

A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding

T. Friščić, I. Halasz, F. C. Strobridge, R. E. Dinnebier, R. S. Stein, L. Fábián and C. Curfs, CrystEngComm, 2011, 13, 3125 DOI: 10.1039/C0CE00894J

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