Issue 27, 2024

Enantioselective merged gold/organocatalysis

Abstract

Gold complexes, because of their unique carbophilic nature, have evolved as efficient catalysts for catalyzing various functionalization reactions of C–C multiple bonds. However, the realization of enantioselective transformations via gold catalysis remains challenging due to the geometrical constraints and coordination behaviors of gold complexes. In this context, merged gold/organocatalysis has emerged as one of the intriguing strategies to achieve enantioselective transformations which could not be possible by using a single catalytic system. Historically, in 2009, this field started with the merging of gold with axially chiral Brønsted acids and chiral amines to achieve enantioselective transformations. Since then, based on the unique reactivity profiles offered by each catalyst, several reports utilizing gold in conjunction with various chiral organocatalysts such as amines, Brønsted acids, N-heterocyclic carbenes, hydrogen-bonding and phosphine catalysts have been documented in the literature. This article demonstrates an up-to-date development in this field, especially focusing on the mechanistic interplay of gold catalysts with chiral organocatalysts.

Graphical abstract: Enantioselective merged gold/organocatalysis

Article information

Article type
Highlight
Submitted
09 jan 2024
Accepted
29 fev 2024
First published
29 fev 2024

Chem. Commun., 2024,60, 3607-3623

Enantioselective merged gold/organocatalysis

C. Pegu, B. Paroi and N. T. Patil, Chem. Commun., 2024, 60, 3607 DOI: 10.1039/D4CC00114A

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