Issue 23, 2022

Recent research progress of red-emitting/near-infrared fluorescent probes for biothiols

Abstract

Small-molecule biological thiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), occupy a vital position in physiological and pathological activities. Abnormal fluctuations of their concentrations are often closely connected with a variety of diseases. Rapid and accurate detection of these biothiols is of great importance. Due to the advantages such as low background interference, strong tissue penetration and less damage to biological samples, studies on red-emitting/near-infrared fluorescent probes have attracted great interest from researchers. Many red-emitting/near-infrared fluorescent probes for biothiols have been reported. However, there are few reviews about these probes. Here, we focus on the biothiol fluorescent probes with excellent performance and red emission/near-infrared emission signals reported in the past five years (2017–2021). They are classified according to the types of fluorophores constituting the probe molecules, including dicyanoisophorone, tricyanofuran, rhodamine, dipyrrole fluoroboron (BODIPY), cyanine and other fluorophores. The properties of the fluorophores mentioned above are introduced at first. Then the red/near-infrared biothiol fluorescent probes harboring these fluorophores are described in detail from the molecular designs, fluorescence properties, recognition mechanisms, and biological applications. Finally, the problems and development prospects of red/near-infrared biothiol fluorescent probes are discussed. We believe that this brief review can provide a reference for beginners to quickly understand this field and some help for researchers who design novel near-infrared biothiol fluorescent probes.

Graphical abstract: Recent research progress of red-emitting/near-infrared fluorescent probes for biothiols

Article information

Article type
Perspective
Submitted
31 dez 2021
Accepted
01 mai 2022
First published
02 mai 2022

New J. Chem., 2022,46, 10995-11020

Recent research progress of red-emitting/near-infrared fluorescent probes for biothiols

J. Dong, G. Lu, Y. Tu and C. Fan, New J. Chem., 2022, 46, 10995 DOI: 10.1039/D1NJ06244A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements