Issue 14, 2022

Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis

Abstract

Na2B12I12 has many of the properties desired by an X-ray contrast agent but is lethal at the concentrations needed for medical imaging. We demonstrate here that PBS solutions with >50 mM Na2B12I12 induce hemolysis, consistent with the previously reported superchaotropic nature of the anion. The presence of <1 equiv. of 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis and suggests a strategy for exploiting B12I122− as an X-ray contrast agent.

Graphical abstract: Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis

Supplementary files

Article information

Article type
Communication
Submitted
11 nov 2021
Accepted
19 jan 2022
First published
19 jan 2022

Chem. Commun., 2022,58, 2375-2378

Author version available

Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis

S. E. Hollow and T. C. Johnstone, Chem. Commun., 2022, 58, 2375 DOI: 10.1039/D1CC06348K

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