Issue 94, 2021

Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+ T-cells promotes their mechanotransduction and activation

Abstract

We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

Graphical abstract: Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+ T-cells promotes their mechanotransduction and activation

Supplementary files

Article information

Article type
Communication
Submitted
14 set 2021
Accepted
04 nov 2021
First published
04 nov 2021

Chem. Commun., 2021,57, 12667-12670

Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+ T-cells promotes their mechanotransduction and activation

R. Li, W. Ali, C. Ma, A. Bajpai, N. Luu, A. Varshney, C. R. Rowe and W. Chen, Chem. Commun., 2021, 57, 12667 DOI: 10.1039/D1CC05194F

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