Issue 46, 2020

Bioactive metal-containing nanomaterials for ferroptotic cancer therapy

Abstract

The clinical performance of the current cancer therapies is still far from satisfactory. The emerging ferroptosis-driven therapy strategies reignite the hope of chemotherapy in tumor treatment due to their incredible tumor suppression. Among ferroptosis-based cancer therapies, metal elements have attracted remarkable attention due to their inherent physicochemical properties in inducing ferroptosis of tumor cells quickly and strongly without complex cellular signal transduction. Although the discovery and applications of ferroptosis for tumor treatment have been discussed in many reviews, the unique advantages of metal-containing nanomaterials interfering ferroptotic cancer therapies (MIFCT) have seldom been mentioned. Here, we outline the latest advances of MIFCT comprehensively. Firstly, the functions of different kinds of metal elements or their ions are introduced to illustrate their advantages in MIFCT. Secondly, the emerging metal-containing nanomaterials that are designed to achieve ferroptosis-driven therapy are overviewed, including their ability to boost the Fenton or Fenton-like reaction for reactive oxygen species generation, act as hydrogen peroxide self-providers, damage the reducing system, and disturb cellular communication. Moreover, metal-containing nanomaterials with external energy conversion features for MIFCT are discussed. Finally, the future expectations and challenges of MIFCT for clinical cancer therapy are spotlighted.

Graphical abstract: Bioactive metal-containing nanomaterials for ferroptotic cancer therapy

Article information

Article type
Review Article
Submitted
03 set 2020
Accepted
03 nov 2020
First published
04 nov 2020

J. Mater. Chem. B, 2020,8, 10461-10473

Bioactive metal-containing nanomaterials for ferroptotic cancer therapy

W. Fei, Y. Zhang, Y. Ye, C. Li, Y. Yao, M. Zhang, F. Li and C. Zheng, J. Mater. Chem. B, 2020, 8, 10461 DOI: 10.1039/D0TB02138E

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