Issue 48, 2020

Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases

Abstract

Inflammation is ubiquitous in the body, and uncontrolled inflammation often contributes to various diseases. Celastrol, a compound isolated from a Chinese medicinal herb, holds great potential in treating multiple inflammation-associated diseases. However, its further clinical use is limited by its poor solubility, bioavailability, and high organ toxicity. With the advancement of nanotechnology, the nano-delivery of celastrol can effectively improve its oral bioavailability, maximize its efficacy and minimize its side effects. Here, we summarize the roles of celastrol in the treatment of various inflammation-associated diseases, with a special emphasis on its role in modulating immune cell signaling or non-immune cell signaling within the inflammatory microenvironment, and we highlight the latest advances in nano-delivery strategies for celastrol to treat diseases associated with inflammation.

Graphical abstract: Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases

Article information

Article type
Review Article
Submitted
11 ago 2020
Accepted
13 out 2020
First published
15 out 2020

J. Mater. Chem. B, 2020,8, 10954-10965

Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases

G. Fang and B. Tang, J. Mater. Chem. B, 2020, 8, 10954 DOI: 10.1039/D0TB01939A

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