Issue 34, 2020

Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Abstract

A Knoevenagel condensation of various aldehydes with malononitrile effectively proceeded in the presence of hydroquinone/benzoquinone mixed catalysts at room temperature in H2O. Furthermore, γ-deuterium-labeled α,β-unsaturated nitrile derivatives were also constructed via a deuteration of an aliphatic aldehyde in D2O using a basic resin and the subsequent Knoevenagel condensation.

Graphical abstract: Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Supplementary files

Article information

Article type
Communication
Submitted
07 jul 2020
Accepted
12 ago 2020
First published
13 ago 2020

Org. Biomol. Chem., 2020,18, 6594-6597

Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

R. Takakura, K. Koyama, M. Kuwata, T. Yamada, H. Sajiki and Y. Sawama, Org. Biomol. Chem., 2020, 18, 6594 DOI: 10.1039/D0OB01397H

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