Issue 23, 2019

N-Heterocyclic carbene catalysed umpolung reactions of imines approaching enantioselective synthesis

Abstract

N-Heterocyclic carbenes (NHCs) have emerged as efficient catalysts for promoting umpolung reactions of aldehydes and enals. To a certain extent, the NHC catalyzed umpolung reactions of Michael acceptors are also reported. Recently, the NHCs have been successfully used for catalysing the umpolung reactions of aldimines through the formation of aza-Breslow intermediates. The initial reports on the chiral NHC-catalysed enantioselective umpolung reactions of imines are turning out to be very promising to achieve a high level of enantio-induction. This highlight article focuses on the NHC catalysed umpolung reactions of aldimines, with a special emphasis on the corresponding enantioselective transformations.

Graphical abstract: N-Heterocyclic carbene catalysed umpolung reactions of imines approaching enantioselective synthesis

Article information

Article type
Highlight
Submitted
01 set 2019
Accepted
19 out 2019
First published
21 out 2019

Org. Chem. Front., 2019,6, 3821-3824

N-Heterocyclic carbene catalysed umpolung reactions of imines approaching enantioselective synthesis

P. Chauhan, Org. Chem. Front., 2019, 6, 3821 DOI: 10.1039/C9QO01074B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements