Issue 17, 2018

A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

Abstract

Here, we propose a highly sensitive and rapid bio-sensor for the detection of bio-markers for stroke and cancer-related diseases, based on the utilization of the adsorption properties of ruthenium carbonyl (Ru–CO) clusters on monolayer graphene (MG). A fast rate of decarbonylation of Ru–CO to form ruthenium oxide nanoparticles (RuO2 NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO2 NPs. A concentration as low as 17 ng mL−1 of MMP-2 was detected in a simulated clinical serum sample. This effective bio-sensor has the potential to revolutionize the biomedical field in the early detection and possible prevention of stroke and cancer diagnosis.

Graphical abstract: A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

Supplementary files

Article information

Article type
Communication
Submitted
09 fev 2018
Accepted
15 mar 2018
First published
15 mar 2018

J. Mater. Chem. B, 2018,6, 2536-2540

A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

D. Lin, C. Tseng, Q. F. Lim, M. J. Tan and K. V. Kong, J. Mater. Chem. B, 2018, 6, 2536 DOI: 10.1039/C8TB00404H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements