Issue 8, 2018

Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis

Abstract

Salviyunnanone A (1), a cytotoxic diterpenoid possessing an unprecedented 7/5/6/3 ring system derived from a normal abietane skeleton, was characterized from Salvia yunnanensis. Its structure was established by extensive MS and NMR spectroscopic analyses and its absolute configuration was defined by the comparison of experimental and calculated ECDs. The synthetic study of 1 was carried out and its 6-epi-isomer (12) was achieved in 9 steps involving the conjugated addition of an aryl boronic acid as a key step.

Graphical abstract: Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis

Supplementary files

Article information

Article type
Research Article
Submitted
21 dez 2017
Accepted
19 fev 2018
First published
19 fev 2018

Org. Chem. Front., 2018,5, 1262-1266

Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis

F. Xia, D. Zhang, C. Wu, H. Geng, W. Xu, Y. Zhang, X. Yang, H. Qin and G. Xu, Org. Chem. Front., 2018, 5, 1262 DOI: 10.1039/C7QO01140G

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